TIP: Don't run the AMD Driver Cleaner Utility on Windows 8 or 8.1

Ok, let me repeat this a couple of times:

Ok, got your attention?

Check out this link on Guru3D for the details, basically it breaks a lot of things in Windows. In my case I stumbled onto it because the NTFS permissions dialog no longer opened. The only way to resolve it for me turned out to be to start setup from Windows itself and pick the Upgrade option (basically doing an in-place reinstall, keeping apps & settings).